Unai Emery confirmed the Welshman asked to remain in London with wife Colleen expecting twins.
Speculation is rife regarding Ramsey’s Arsenal future after the club withdrew a contract offer.
The midfielder is out of contract next summer and is able to talk with foreign clubs over a free transfer in January.
Emery said: “Ramsey asked me if he can stay in London because his wife is pregnant and they are waiting on the doctors.”
Arsenal will also be without Pierre-Emerick Aubameyang (illness) and Petr Cech (hamstring) for the match in Azerbaijan.
While Henrikh Mkhitaryan has not travelled due to tension between the country and his native Armenia.
But Emery is still set to name a strong line-up as he looks to secure qualification from the group stage as quickly as possible.
Emery added: “The best idea is to think only of the match tomorrow and with the respect for this competition because we want, at the end, to finish first in the group.
“We want to win tomorrow with the best players for playing.”
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