Rob Barlow, 75, and his wife Clare, 51, had booked the trip to Salou with TUI last August.
They booked a week at the H10 Salou Princess thinking it would be an ideal break.
Rob said: "This time last year, she [Clare] was diagnosed with a tumour in her kidney and had to go to Morriston to have her kidney out.
"We had to pull out of a holiday, so we asked if we could defer the holiday to August when we knew Clare would be better.
"I'm retired now, but Clare is 25 years younger and she's still working as a cook in a primary school and was off for six months so we were really looking forward to his holiday."
But it was while on holiday that things started to go wrong for the pair after using the hot tub on the resort.
He said: "We had been sat on the balcony and somehow I crossed my legs and I nipped the skin on my left foot.
"Clare cleaned it up a bit and put a double plaster on it and I thought nothing else about it."
They then found a hot tub in the resort away from the noise.
He said: "We discovered the Jacuzzi on the sun deck and started using it because it was nice and quiet.
"The day before we came home I was shaking and had to get extra duvets out of the cupboard. I really didn't feel well.
"We flew back to Cardiff on the Tuesday and by Wednesday, my foot had started to go black."
He was taken taken to the Princess of Wales hospital in Bridgend where he was kept in for four days and treated with antibiotics.
He said: "They kept me in hospital in Bridgend and I had tests.
"Then the consultant said we're moving you to Morriston because you're going to have your little toe off.
"I was flabbergasted. The infection had gone up and I had a 1cm x 3cm hole in the top of my instep.
"It's healed up now slowly, but I go every three days to have my dressing changed."
After the incident, he contacted TUI to complain, and filled in a claim form sent by the company.
The last letter he received told him they were going to the insurance company, but it might take up to six months, which has left Rob "disgusted" with the company.
He said: "I told them they're playing for time and messing us about. I don't want people going to that hotel and have that happen to them.
"It's the same water going pumped around. Because it was 32/33C, it was probably the worst thing I could have gone into.
"The infection had got into the cut in my little toe.
"I couldn't move for the first two or three months and just last week, I was able to get a trainer on my foot. You don't expect these things to happen.
"You go away on holiday and this happened to me but it's the attitude of TUI that annoys me. They just don't give a damn."
A TUI UK spokeswoman said Sun Online Travel: "We’re sorry to learn of Mr Barlow’s experience. As this is a serious situation which we are currently investigating, we’re unable to comment further."
A Thomas Cook holiday ended in disaster after an exploding shower door knocked a man out, leaving him unconscious and bloody, Sun Online Travel reported.
Sarah and Scot Field were on their honeymoon with their four children when the glass door broke.
He was rushed to hospital and had to have surgery to remove glass from his wrist.
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