Raheem Sterling scored twice, while Sergio Aguero scored his 150th Prem goal for the club.
Later, Alvaro Morata continued his fine form with another pair of goals for Chelsea in a 3-1 win against Crystal Palace.
The Eagles had levelled but Morata and then Pedro scored to continue Maurizio Sarri's unbeaten start to the season.
MAN CITY 6 SOUTHAMPTON 1
CHELSEA 3 CRYSTAL PALACE 1
You can also catch up with all the goals from Saturday's action below:
Bournemouth 1 Manchester United 2
Cardiff 0 Leicester 1
Everton 3 Brighton 1
Newcastle 1 Watford 0
West Ham 4 Burnley 2
Arsenal 1 Liverpool 1
Wolves 2 Tottenham 3
Source: Read Full Article