The Sweden defender was ill during the recent national team break but still ended up playing twice, including a full 90 minutes against Russia.
Lindelof was then thrust straight back into United’s line-up for Saturday’s 0-0 draw with Crystal Palace.
However, the 24-year-old didn’t leave Old Trafford unscathed, having picked up a hamstring injury during the second half.
And he was forced to continue playing as United had already made all three of their changes.
Mourinho has hailed Lindelof for battling on, and hopes he will return to the scene quickly.
Mourinho told MUTV: “I believe [he is injured]. I have to believe so.
“I always say this is the period of the injuries. If they are not injured with the national teams, they come to the clubs and are injured.
“He played against Russia three days ago or two days ago, but of course we need him when he plays.
“He was probably our best player. He was a brave lad, but he probably punished himself. I don’t know how long he will be out, but he is a fantastic example.”
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