Pep Guardiola's side have already negotiated their safe passage through to the knockout stages, but will want to top the group by picking up three points here.
The visitors currently sit bottom of the table but have put up an excellent fight in their maiden Champions League.
But they're yet to win in the competition and would love to bow out with three points on the road.
What time is kick-off?
THIS Group F finale is all set for Wednesday, December 12.
Kick-off at the Etihad is at 8pm.
When the sides met earlier in the competition, City needed a late winner to see off the Bundesliga side 2-1.
Which TV channel can I watch it on and can I live stream?
THE game will be shown live on BT Sport 2 and 4K UHD from 7.30pm.
If you're a BT customer, you can stream the match using the App on your mobile, tablet or Windows 10 PC.
SunSport will be running their usual LIVE BLOG from Eastlands, which will keep you instantly up to date with any goals or talking points.
What is the team news?
WITH City already through, injured Sergio Aguero will likely sit this one out once again.
David Silva picked up a knock in the loss against Chelsea and Guardiola will assess the Spaniard's fitness before gameday.
Hoffenheim will have to make do without suspended pair Adam Szalai and Kerem Demirbay.
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