Mourinho was dumped by the Old Trafford board following the club's dismal performances this season.
Mourinho has left Old Trafford after the club made the worst start to a season for 28 yearsUnited are slumped down in sixth place in the Premier League, 19 points behind leaders Liverpool, after their worst start to a campaign in 28 years.
And Mourinho was sent packing less than 48 hours of the club's 3-1 thrashing by their old rivals at Anfield.
Michael Carrick has been asked to take charge of the side – just six months after he quit playing to begin his coaching career.
A United statement said: "Manchester United announces that manager Jose Mourinho has left the club with immediate effect.
"The club would like to thank Jose for his work during his time at Manchester United and to wish him success in the future.
"A new caretaker manager will be appointed until the end of the current season, while the club conducts a thorough recruitment process for a new, full-time manager."
Mourinho, 55, only signed a new contract last January which was supposed to keep him at Old Trafford until 2020.
And in sacking him so soon after that extension, it left United liable for having to fork out £24million to pay him off.
It brings to an end a tumultuous spell in charge of United which has been beset by fall-outs with his players – in particular star midfielder Paul Pogba.
The former Chelsea boss delivered the Europa League and EFL Cup in his first season in charge, having taken over from Louis van Gaal in 2016.
But that was as good as it got for Mourinho, although he did lead them to an improved second place finish last season – some 19 points adrift of winners Manchester City.
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