The visitors were in Champions League action on Tuesday, beating Young Boys to book their place in the knockout stages and now face a Saints side who have struggled so far this season with only one win.
What time is kick-off?
This game takes place on Saturday, December 1.
It will be held at Saint Mary's Stadium.
Kick-off is at 5.30pm.
Which channel is it on and can I live stream it?
You can watch this game live on BT Sport 1, with coverage starting at 5pm.
Alternatively, you can keep up-to-date with all the latest action on the SunSport LIVE BLOG.
What is the team news?
There is no injury or suspension concerns for Jose Mourinho but Diogo Dalot and Marcus Rojo are back in training
Manchester United are without Victor Lindelof, who was injured in the game with Crystal Palace last weekend.
For Southampton, they will be waiting on a late fitness test from Danny Ings.
The 26-year-old forward has been struggling with a hamstring injury.
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