Each will be hoping for three points after the match in Istanbul two weeks ago ended in a goalless draw, with the top two spots in Group D still up for grabs.
What time does Schalke 04 v Galatasaray kick off?
This game takes place on Tuesday, November 6.
It will be held at the Veltins-Arena, Gelsenkirchen.
Kick-off is at 8.00pm.
What TV channel is Schalke 04 v Galatasaray on and can I live stream it?
The match is being shown in the UK on BT Sport Extra 4.
What is the team news?
For the home side, left-back Hamza Mendyl is likely to continue his recovery from an ankle injury, while midfielder Bastian Oczipka remains a long-term absentee.
Galatasaray will also be without their left-back Yuto Nagatomo, who suffered a collapsed lung last month. Emre Akbaba and Fernando are still sidelined, but striker Eren Derdiyok may return.
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