The winners of this replay will visit Chelsea, but the Hatters will have to cope without boss Nathan Jones who left to join Stoke last week.
What time is kick-off?
THIS game is set for Tuesday, January 15.
Kick-off is at 7.45pm.
The last time these two sides met on this ground, Luton ran out 3-2 winners in a 2007 Championship clash.
Is Luton vs Sheffield Wednesday on TV and can I live stream it?
SADLY this game isn't being broadcast live in the UK.
The TV game chosen for coverage is the replay between Blackburn and Newcastle United at Ewood Park.
Here at SunSport we have you covered, with our LIVE BLOG from Luton keeping you up to date with all the action as it happens.
What is the team news?
Luton will be without Danny Hylton, who is suspended after being sent off in the Hatters' draw at Sunderland.
Harry Cornick is a doubt after not playing since New Year's Day.
Sam Hutchinson is 50/50 to feature in the game for Sheffield Wednesday after picking up a knock at the weekend while Keiren Westwood (toe) and midfielder Joey Pelupessy (ankle) are also doubts.
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