Key trio Dele Alli, Harry Kane and Son Heung-min are all set to miss the all-London FA Cup tie.
And the Eagles will have fond memories of their last FA Cup tie against Spurs when they won 1-0 at White Hart Lane on their way to the 2016 final.
When is Crystal Palace vs Tottenham?
Crystal Palace will take on Tottenham on Sunday, January 27.
The match will kick off at 4pm.
It will be played at Selhurst Park.
What TV channel is Crystal Palace vs Tottenham on and can I live stream it?
Crystal Palace vs Tottenham will be live on BT Sport 2.
Coverage will commence half an hour before kick-off at 3.30pm.
To stream the game live, head to BTSport.com or download the BT Sport app.
You can also follow all the action on the SunSport LIVE BLOG.
How do I watch Crystal Palace vs Tottenham for free?
EE phone subscribers can catch the game for FREE by texting SPORT to 150 and following the instructions for a three-month trial.
GIANT KILLINGS Remember these MASSIVE shocks? Test your FA Cup knowledge right here
What is the latest team news?
Further team news to follow…
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