But the Lions star could make a comeback against Italy or Scotland towards the end of the Championship.
As SunSport exclusively revealed, Itoje's Saracens team-mate Nick Isiekwe has been called up as his replacement.
England said: "Maro Itoje is expected to be available towards the end of the tournament."
The Red Rose got together at their Bagshot base this morning after boss Eddie Jones gave them two days off following the famous win in Dublin.
But centre Jonathan Joseph isn't involved after he stepped up his recovery from ankle surgery by playing for Bath in the Premiership Rugby Cup last night.
Forwards
Jack Clifford (Harlequins)
Dan Cole (Leicester Tigers)
Luke Cowan-Dickie (Exeter Chiefs)
Tom Curry (Sale Sharks)
Ben Earl (Saracens) *
Ellis Genge (Leicester Tigers)
Jamie George (Saracens)
Nathan Hughes (Wasps)
Nick Isiekwe (Saracens)
George Kruis (Saracens)
Joe Launchbury (Wasps)
Courtney Lawes (Northampton Saints)
Ben Moon (Exeter Chiefs)
Brad Shields (Wasps)
Kyle Sinckler (Harlequins)
Jack Singleton (Worcester Warriors) *
Billy Vunipola (Saracens)
Mako Vunipola (Saracens)
Harry Williams (Exeter Chiefs)
Mark Wilson (Newcastle Falcons)
Backs
Chris Ashton (Sale Sharks)
Mike Brown (Harlequins)
Joe Cokanasiga (Bath Rugby)
Elliot Daly (Wasps)
Ollie Devoto (Exeter Chiefs)
Owen Farrell (Saracens) captain
George Ford (Leicester Tigers)
Jonny May (Leicester Tigers)
Jack Nowell (Exeter Chiefs)
Dan Robson (Wasps) *
Henry Slade (Exeter Chiefs)
Ben Te’o (Worcester Warriors)
Ollie Thorley (Gloucester Rugby) *
Manu Tuilagi (Leicester Tigers)
Ben Youngs (Leicester Tigers)
*uncapped
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