Both teams are locked on three points in Group I after the Turkish giants lost to Malmo and the Belgian's were thumped 3-1 by Sarpsborg.
What time is kick-off?
This match will take place on Thursday, October 25.
It will kick-off at 8pm.
Vodafone Park in Istanbul will host the showdown.
Which TV channel is it on and can I live stream it?
This match will not be shown live on television.
But you can keep up to date with all of the action on the SunSport live blog.
What is the team news?
Besiktas are expected to be without former Barcelona defender Pepe because of injury.
Left-back Adriano is out action and Adem Ljajic will continue his stint on the sidelines with a groin problem.
Mertcan Acikgoz suffered a cruciate ligament rupture last month and is not expected to return until March.
And Alpay Celebi also suffered the same injury, but he is predicted to be unavailable until April.
For Genk, defensive midfielder Vladimir Screciu will miss out due to a fracture.
Sander Berge is out with knee problem and Leandro Trossard will spectate from the sidelines with a hamstring injury.
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