The idea of going near a venomous toad isn’t exactly appealing, but the animal could hold the key to treating depression and anxiety.
Scientists at Johns Hopkins Medicine have discovered that a psychedelic found in toad venom appears to improve depression and anxiety symptoms.
The psychedelic, called 5-MeO-DMT, is found in the venom of Befo Alvarius toads, as well as a range of plant species.
To test its effect on humans, the researchers gave small doses to 362 adults with depression or anxiety.
Amazingly, around 80% of participants reported improvements in anxiety and depression after using the psychedelic.
The researchers believe that these effects may be linked to one of the unique properties of 5-MeO-DMT – the fast action and short duration of its psychedelic effects.
Dr Alan Davis, an author of the study, said: “Research has shown that psychedelics given alongside psychotherapy help people with depression and anxiety.
“However, psychedelic sessions usually require 7 – 8 hours per session because psychedelics typically have a long duration of action.
“Because 5-MeO-DMT is short-acting and lasts approximately 30-90 minutes, it could be much easier to use as an adjunct to therapy because current therapies usually involve a 60 – 90 minute session.”
While initial studies have shown that 5-MeO-DMT is safe to use in low doses, the researchers highlight that further research is needed before the psychedelic is prescribed for depression or anxiety.
Dr Davis added: "It is important to examine the short- and long-term effects of 5-MeO-DMT, which may enhance mood in general or may be particularly mood enhancing for those individuals experiencing clinically significant negative mood.
"Regardless, this research is in its infancy and further investigation is warranted in healthy volunteers.”
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