Armed cops from Greater Manchester Police were called to Claremont Road at 2.30am this morning and discovered several people had been injured.
The injuries range from minor to major, but most do not appear to be life-threatening, the force said.
Footage reportedly showing the aftermath of the incident was posted on social media.
The video appears to show a panicked group of people being helped by police.
As a voice cries out, shouts of "move" can be heard, while another voice asks "can you hear me".
A number of people were in the area following the Caribbean Carnival, which had finished some hours before, the force added.
One local said on Twitter: "Sad to wake up to news of 10 people being shot in Moss Side.
"The carnival was the best atmosphere and I didn't see a hint of trouble from 1-7pm when I was there.
"People just there with friends and family dancing to great music."
Detective Superintendent Debbie Dooley said: "We currently have a number of people in hospital all being treated for different injuries but thankfully most do not appear to be life-threatening at this time.
"Officers are trying to establish exactly where this incident took place and who is responsible for such a dangerous attack.
"Those living or visiting the area will understandably be concerned by this incident and we will have extra officers patrolling the area throughout the morning and into the coming days."
GMP said it had deployed a "large number" of armed and unarmed officers in the area after the alarm was raised.
Investigations were taking place to identify exactly where the shooting occurred and who was involved.
Anyone with any information was asked to call police on 0161 856 4166 quoting incident number 297 of 12 August or the independent charity Crimestoppers anonymously on 0800 555 111.
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