Young striker Patrick Cutrone hit the target twice to make it a great night for fans of the Italian club.
Meanwhile, Sporting Lisbon scored two goals at the death to complete a 2-1 turnaround against Vorskla.
German giants Bayer Leverkusen ran out 4-2 victors over AEK Larnaca.
While RB Leipzig left Rosenborg with a 3-1 win under their belts.
Russian aces Zenit St Petersburg were made to work for a 1-0 win against Slavia Prague.
While Fenerbahce beat Spartak Trnava 2-0 in Turkey.
Real Betis triumphed 3-0 over F91 Dudelange.
But there was misery for Anderlecht as they were beaten 2-0 at home by Dinamo Zagreb.
French aces Bordeaux also lost at home, falling to a 2-1 defeat against Danes FC Copenhagen.
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