The England international collided with the advertising hoardings and was replaced by Trent Alexander-Arnold in the 23rd minute.
The injury looks be to his ankle and will come as a massive blow to Jurgen Klopp ahead of the heavily congested festive schedule.
Gomez has been revelation for the Reds this season.
He has been instrumental in the line-up with Virgil Van Dijk -and has contributed significantly to their nine clean sheets this term.
Liverpool are hoping for a win against Burnley to keep the pressure on Man City.
Guardiola's men won 2-1 against Watford last night to stretch the gap to five.
And the Reds have been on great league form recently – wining four of their last five matches.
Their last win came against bitter rivals Everton on Sunday – where Klopp was fined for his celebrations.
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