Spurs were in action as recently as Monday when they lost 1-0 to Premier League champions Manchester City at Wembley.
But less than 48 hours on they travel to the London Stadium to face a Hammers side who drew with Leicester City at the weekend.
Both sides met in the Premier League just 11 days ago,with Erik Lamela heading home the only goal as Spurs prevailed.
What time is kick-off?
The Hammers host Spurs in East London TONIGHT, October 31.
Kick-off at the London Stadium is at 7:45pm.
Both sides met at the same stage of the competition last season, with the East Londoners producing a fine comeback from two goals down to win 3-2 at Wembley.
Which TV channel can I watch it on?
Unfortunately the game is not available to watch on TV in the UK.
Broadcasters have opted to instead show Frank Lampard's managerial return to Chelsea with Derby County as their feature game on Wednesday.
However, SunSport will be running our LIVE BLOG, which will provide minute-by-minute updates from the game.
What is the team news?
Both teams are expected to ring the changes for the round-of-16 clash.
Academy graduates Grady Diangana, Joe Powell and Conor Coventry all made their West Ham debuts in the last round and could all feature again.
Forty-eight hours on from the defeat to City, Pochettino is likely to make a host of alterations.
Paulo Gazzaniga, Serge Aurier, Harry Winks and Fernando Llorente can all expect to be involved for Tottenham.
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