The Cheltenham Festival victor is the current favourite for the Gold Cup and heads a possible field of 21 for the top-level event.
A sensational winner of the RSA Chase last season, Pat Kelly's staying phenomenon is widely believed to be a Gold Cup hero in waiting.
However, this will be his first real test in open company and he's taking on the best in the business from across the Irish Sea.
Perhaps the most potent of his rivals will be impressive JNwine Champion Chase winner Road To Respect.
Noel Meade's challenger has been progressing steadily and will bid to repeat his heroics in last year's contest.
Gigginstown have entered nine others, including former winner Outlander, last year's Ryanair winner Balko Des Flos and dashing grey Disko.
A Toi Phil, Don Poli, Alpha Des Obeaux, Tout Est Permis, Sub Lieutenant and Shattered Love complete the potential ten-strong challenge from Michael O'Leary's powerhouse.
Willie Mullins also has a classy team entered for the contest including last year's Irish National fifth Bellshill, recent Clonmel Oil winner Kemboy and promising chaser Al Boum Photo.
Total Recall and Invitation Only are the other confirmations from Closutton.
Monalee, Anibale Fly, Edwulf, Coney Island and The Storyteller complete the possible field.
Later in the week, Samcro is the headline dish in the Ryanair Hurdle.
Gordon Elliott's star was put firmly in his place by Buveur D'Air in the Fighting Fifth at Newcastle but won't have to face Nicky Henderson's contender this time.
Among those that could take him on are Champion Hurdle runner-up Melon, awesome mare Laurina, recent Morgiana winner Sharjah and the improving Bedrock.
Supasundae, Apple's Jade, Limini, Farclas, Petit Mouchoir and Tombstone are other possibles for the Grade 1 contest.
The Neville Hotels Novice Chase has attracted 14 rivals and it could see a rematch between Delta Work and Le Richebourg.
The pair fought out the finish to the Drinmore at Fairyhouse last time and both will step up trip to three miles.
Five-time seeker Judgement Day will step up markedly in class for Henry De Bromhead, while Champagne Classic could have his first outing since winning a Grade 1 at the Punchestown Festival in 2017.
Ben Dundee, Blow By Blow, Burren Life, Chris's Dream, Minella Fair, Moonshine Bay, Mortal, Nick Lost and Majurca complete the potential line-up.
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