Jurgen Klopp's side need to take three points off the Italians to have any chance of qualifying for the Champions League knockout stages.
What time is kick-off?
THIS crucial Champions League group tie is set for Tuesday, December 11.
Kick-off at Anfield is at 8pm.
Napoli won a fiercely-contested clash 1-0 back in October which has put them in the driving seat to qualify.
Which TV channel can I watch it on?
TUNE into BT Sport 2 or 4K UHD to watch the match live on Tuesday evening.
If you're a BT subscriber, live streaming is easy on your mobile, tablet or laptop by downloading the BT Sport app.
And here on SunSport we will be providing a LIVE BLOG from Anfield, which will update you with all the drama as it happens.
What is the team news?
LIVERPOOL have been handed a welcome boost with the news that Sadio Mane is fit to return to action.
Adam Lallana has no lasting effects from a head injury sustained at Bournemouth, whilst Dejan Lovren will be a game-time decision.
Napoli centre-back Kalidou Koulibaly is on the cusp of a suspension, whilst the visitors will be without Simone Verdi and Vlad Chiriches.
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