The home side, who are third in the table with 19 points, head into the game after a 5-1 win over Dudelange in the Europa League.
What time is Olympiakos vs Panathinaikos?
This match will take place on Sunday, November 11.
It will kick-off at 5:30pm.
The Karaiskakis Stadium will host the showdown.
Which TV channel is it on and can I live stream it?
This match is not available to watch on TV or online in the UK.
But you can keep up to date with all of the action on the SunSport live blog.
What is the team news?
Neither side have any new injury concerns ahead of the huge derby clash.
But Panathinaikos boss Giorgos Dons could be looking to switch his team up after a poor run of results.
The Greek side drew 0-0 with AEK Athens after a 2-0 defeat to PAOK the week before.
Line-ups to follow.
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