The Big Dog relinquished his Universal Championship on Monday Night RAW after announcing he has Leukaemia.
The 33-year-old t0ld the shocked audience he had been fighting the disease for eleven-years in an emotional speech.
The dad-of-three is leaving the WWE for his biggest fight outside the ring, and was backed by wrestlers around the world.
The superstar – real name Leati Joseph Anoa'i – said: "I feel like I owe everyone an apology.
"For months, maybe even a whole year, I've come out here as Roman Reigns and said I'd come out here every week, that I'd be a fighting champion, that I was going to be consistent, that I was going to be a workhorse – but that's all lies.
"It's a lie because the reality is, my real name is Joe and I've been living with leukaemia for 11 years and unfortunately it's back.
"And because the leukaemia is back I cannot fulfil my role. I can't be that fighting champion and I'm going to have to relinquish the Universal Championship.
"I'm not going to lie, I'll take every prayer you can send my way, but I'm not looking for sympathy, I'm not looking for you to feel bad for me because I have faith.
"When I was 22 years old I was diagnosed with this. And very quickly I was able to put it in remission.
"But I'm not going to lie, that was the hardest time of my life. I didn't have a job, I didn't have any money, I didn't have a home and I had a baby on the way and football was done with me.
"But do you want to know who gave me a chance? The team that gave me a chance was the WWE."
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