Michael Bell's Pretty Pollyanna is on a recovery mission after her fourth in the Cheveley Park Stakes on her last start and takes a significant step up in trip.
The filly had been favourite for next season's 1,000 Guineas after her impressive wins in the Duchess Of Cambridge Stakes and the Prix Morny.
Connections have ditched the services of Silvestre De Sousa and booked Danny Tudhope to take the ride on the two-year-old for the first time.
Irish maestro Aidan O'Brien is double-handed as he chases a joint-record sixth victory in the Group 1 contest.
O'Brien first struck gold with Sunspangled 20 years ago and has since added to his tally with Listen (2007), Together Forever (2014), Minding (2015) and Rhododendron (2016).
This year O'Brien saddles Hermosa, who was third in the Moyglare Stud Stakes before winning a Group 3, as well as Moyglare fourth Zagitova.
The Joseph O'Brien-trained Iridessa completes the Irish challengers.
The eight-strong field also includes Ralph Beckett's unbeaten Antonia De Vega.
John Gosden's Shambolic, Charlie Appleby's Beyond Reason and Sir Michael Stoute's Layaleena complete the line-up.
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