The Iberian side currently lead the way by two points and only need to draw to wrap up top spot as the Azzurri will be playing their final match of the group stage.
When does Italy vs Portugal kick off?
This Nations League fixture will take place on Saturday, November 17.
It will kick off at 7.45pm UK time.
That is the same time as in Portugal, while in Italy, it will be 8.45pm.
The match will be held at San Siro in Milan.
Which TV channel is it on and can I live stream it?
This match will be shown live on Sky Sports Football, with coverage underway from 7.40pm.
Sky Sports subscribers will be able to watch the match online and on the Sky Sport Mobile app.
Alternatively, you can keep up-to-date with all action via our dedicated SunSport LIVE BLOG.
What is the team news?
The major absence in this match will be Cristiano Ronaldo for Portugal as he continues to remain unavailable for selection due to the ongoing rape allegations which he firmly denies.
Manchester City's Bernardo Silva has been in hot form this season and will be hoping to provide adequate cover in his absence.
He is just one of five Premier League-based players including Everton's Andre Gomes, Cedric Soares of Southampton and Wolves duo Rui Patricio and Ruben Neves.
Chelsea duo Jorghino and Emerson Palmieri will be looking to stop Portugal, while captain Giorgio Chiellini will be hoping to join an illustrious list of players with 100 Italy caps.
The Azzurri have also called up some young talents for the international break, including Sandro Tonali – with Chelsea among targeting the Brescia midfielder.
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